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Micro Calibrated PQQ-SR
Micro Calibrated PQQ-SR

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Encouraging nerve growth and higher levels of mitochondria is important to your brain’s performance and longevity. Micro Calibrated PQQ-SR can help you get there. Clinically proven to:
  • Stimulate nerve growth factor
  • Protect existing mitochondria from damage
  • Generate new mitochondria
  • Improve cognitive function
  • Increase energy levels
  • Slow the aging process
  • And more!
Prices Starting At: $24.99


30 Veg Caps

Description Flavors, Ingredients and Serving info

An organic molecule naturally occurring in the food supply, PQQ is the first new vitamin discovered since 1948 and has been proposed to be classified as a new B vitamin.. It supports the health and increases production of mitochondria, which generate the energy cells need to function efficiently.*

Because the degradation of mitochondria is a key contributing factor to physiological aging in humans, PQQ may:

  • Slow the aging process*
  • Increase energy levels*
  • Improve cognitive function*
  • Alleviate occasional stress and sleeplessness*
  • Improve cardiovascular function*
  • Improve endurance*
  • Speed recovery*
  • Improve skin*

PQQ supplementation at levels higher than what is found in food has positive effects on cognitive function, immune status, antioxidant status, cardiovascular health, and neurological function. PQQ was found to improve not only immediate memory, but also other higher brain functions such as spatial awareness. The effects of PQQ were enhanced when the substance was used with CoQ10. Researchers found that PQQ taken either alone or in combination with CoQ10 has the potential to prevent, or even reverse, the decline in cognitive function caused by the aging process and oxidative stress.

Micro Calibrated PQQ-SR is a dietary supplement that features MicroPQQ®, a patented form of PQQ. In 2010, MicroPQQ® was recognized by the highly prestigious Nutracon “Best New Finished Product of the Year” award. MicroPQQ® has been used in all of the human clinical studies on PQQ published to date and is the only natural NDI-accepted PQQ on the market. In 2013, MicroPQQ® won the Engredea Editors’ Choice Award for Ingredient with the Best Science.

Mechanism of Action

Double-blind, placebo-controlled human studies have found PQQ improves memory, spatial awareness, and concentration by facilitating nerve regeneration and enhancing nerve growth factor (a protein that promotes the growth, maintenance, and survival of nerve cells).

PQQ helps mitochondria increase in numbers and efficiency so they can help brain cells function more efficiently. The increased synthesis of mitochondria is caused by the activation of two proteins that regulate the expression of genes and the formation of mitochondria:.


PQQ is a safe, naturally occurring essential nutrient found in foods such as kiwi, green peppers, potatoes, tofu and green tea. Micro Calibrated PQQ-SR has been the subject of numerous safety studies, including acute toxicity and genotoxicity studies, in both humans and animals.

Further in Depth Description

Antioxidant Activity

PQQ has been reported to function as an antioxidant and redox modulator in cell culture experiments and in animal models of human diseases. For example, PQQ was an effective antioxidant protecting mitochondria against oxidative stress-induced lipid peroxidation, protein carbonyl formation and inactivation of the mitochondrial respiratory chain. In its reduced form, PQQ exerted greater protection than alphatocopherol (vitamin E) toward the galvinoxyl and peroxyl free radicals, and appeared to have synergistic activity with vitamin E as an antioxidant. Additionally, PQQ is capable of carrying out 20,000 catalytic conversions as an antioxidant, compared to only four for vitamin C.

Cardiac Ischemic Protection

PQQ may be helpful when there is insufficient blood flow to the heart (cardiac ischemia), and it helps protect against oxidative stress in heart muscle cells. The result is less cardiac damage and a reduced incidence of ventricular fibrillation (i.e., abnormal quivering of the heart muscle rather than proper contraction). In animal research, PQQ administration reduced infarct size (i.e., tissue death) in cardiac ischemia, and also protected mitochondria from oxidative damage. Conclusion Whether it achieves recognition as a vitamin, PQQ is an interesting biochemical with an apparent role to play in human health and wellness. To date, published research has been largely limited to laboratory (in vitro) and animal research, with only one unpublished human study cited. PQQ will likely gain more prominence within the scientific community as additional human research is undertaken.

Cognitive Support

Amyloids are fibrous proteins with improper structures. They erroneously interact with one another or other cell components, resulting in the formation of fibrils (i.e, fine fibers). Amyloids are associated with the pathology of many human diseases, including Alzheimer’s disease and other neurodegenerative disorders. In animal research, PQQ was shown to inhibit the amyloid fibril formation of the amyloid protein, beta amyloid (the major amyloid implicated in Alzheimer’s) and dramatically inhibit mouse prion protein. The researchers concluded that PQQ has potential to become a leading anti-neurodegenerative compound in the treatment of neurodegenerative diseases. In addition, beta amyloid has been shown to cause neurotoxicity in Alzheimer’s disease by evoking a cascade of oxidative damage to neurons. In laboratory research, PQQ was shown to help protect against this type of oxidative damage and subsequent neurotoxicity caused by beta amyloid. In 2007, a human double-blind, placebo-controlled clinical trial was Redox Defined Redox refers to reactions in the body in which a molecule or atom has lost an electron (oxidation) or gained an electron (reduction). This is the process that generates free radication (oxidation) and quenches them with antioxidants (reduction). Redox reactions are also involved in the oxidation of glucose in the human body through a series of complex electron transfer processes, ultimately yielding ATP (the energy “currency” of the body). A clinical trial was conducted in Japan using PQQ. Seventy-one subjects between the ages of 40 and 70 years were supplemented with a placebo, with 20 mg of PQQ daily, or with 20 mg of PQQ along with 300 mg of coenzyme Q10 (CoQ10). The results showed improvements on tests of higher cognitive function in the PQQ group compared to the placebo group. In the PQQ + CoQ10 group, results were even greater; this may be a result of the fact that both PQQ and CoQ10 are involved in energy metabolism in the mitochondria.

Energy Metabolism

Mitochondria are the cellular organelles that manufacture the body’s energy “currency,” ATP. In laboratory research, PQQ was shown to stimulate mitochondrial activity. In fact, PQQ stimulate mitochondrial biogenesis, suggesting that it may be beneficial in diseases associated with mitochondrial dysfunction. Furthermore, research in mice showed that those supplemented with PQQ had 20 to 30 percent more mitochondria than PQQ-deficient mice.

Immune Support

The importance of PQQ to immune health is evident when it is omitted from chemically defined diets, resulting in compromised immune responsiveness. Specifically, PQQ deprivation results in a reduction in interleukin-2 (IL-2), a loss of B- and T-cell sensitivity to mitogens. Conversely, oral supplementation of PQQ increases the responsiveness of B- and T-cells to mitogens (chemical substances that encourage a cell to commence cell division).

Micro Calibrated PQQ-SR formulated for enhanced Bioavailability
MicroPQQ® is a specially formulated PQQ preparation that combines a bioadhesive polymer, natural wax, and J3-cyclodextrin to enhance dissolution and absorption in the human body, leading to higher levels of availability. In a dissolution test, the dissolution profile shows a sustained release of PQQ from the MicroActive® formulation. By 121 minutes, 95% of the dose was in solution in a micronized form, with less than a 10-micron particle size. With the control PQQ powder, 100% of the dose was in solution by 360 minutes.

The MicroActive formulation may enhance the beneficial effects in vivo by enabling the serum levels to be maintained for a longer time. This was shown in a bioavailability clinical study in two healthy subjects using MicroPQQ formulation and PQQ powder with doses equivalent to 40 mg of PQQ. The uptake of PQQ from MicroPQQ reached a maximum blood level at 2 hours, followed by sustained release for up to 9 hours. The plasma levels remained high at 9 hours, indicating a sustained release longer than 9 hours. In contrast, the control PQQ powder showed a maximum blood level at 2 hours and the plasma level was back to baseline by 9 hours. The average area under the curve for MicroPQQ was 69.66, whereas the control PQQ was only half as much, with a value of 31.41. The ratio of the area under the curve (sustained plasma concentrations) of MicroActive to the control PQQ was 2.2 times higher.

Human studies: improvement of cerebral function and metabolism

The effect of PQQ on cerebral function and anti-stress activity was tested in 71 human subjects over a 12-week period (Nakano, 2009). The double-blind, placebo-controlled study used 20 mg of PQQ and 20 mg of PQQ with 100 mg of CoQ10 in the form of a test food. PQQ exerted an improvement in cerebral function, and improvements were found in high-level cerebral functions, including attention and information discriminating and processing abilities, more so than of memory.

PQQ and PQQ with CoQ10 improved high-level cerebral functions in healthy middle-aged and older adults. The metabolic effects of PQQ were investigated with dosages ranging from 0 to 40 mg per day (Harris, 2013). Decreases in levels of C-reactive protein (CRP) of 10–40% on average occurred, though the pretreatment values were considered normal. CRP was dramatically lowered in male subjects by almost 90% on average. Plasma mDNA levels were elevated following treatment, indicating increases in mitochondria synthesis. The physiological responses from PQQ were with doses that were on average 30 mg per day or lower.

A placebo-controlled, double-blind, parallel study was undertaken to see how PQQ could improve memory and other measures of cognitive function in subjects ages 50 to 70 experiencing forgetfulness. Subjects took PQQ alone, PQQ with CoQ10, or placebo for 24 weeks (Koikeda, 2011). They were evaluated using a test assessment of neuropsychological status. The study found that PQQ taken either alone or with CoQ10 had the potential to prevent or even reverse cognitive decline. PQQ improved not only immediate memory but also other higher brain functions such as spatial awareness.

Seventeen adult male and female subjects participated in a clinical trial to evaluate the effectiveness of a 20-mg dose of PQQ on stress, fatigue, quality of life, and sleep. They ingested 20 mg of PQQ daily for 8 weeks. All six measures of vigor, fatigue, tension-anxiety, depression, anger-hostility, and confusion were significantly improved following PQQ administration compared with before use. Measures for quality of life, appetite, sleep, obsession, and pain also improved significantly. Significant improvement in sleepiness at awakening, sleep onset and maintenance, and sleep duration was found. The changes in these global scores were correlated with decreases in cortisol (Nakano, 2012).

Chowanadisai W, M. Nakano. Potential physiological importance of pyrroloquinoline quinone. Altern Med Rev. 2009; 14(3): 268–77.
• Chowanadisai W, K.A. Bauerly, E. Tchaparian, A. Wong, G.A. Cortopassi, R.B. Rucker. Pyrroloquinoline quinone stimulates mitochondrial biogenesis through cAMP response element-binding protein phosphorylation and increased PGC-1 alpha expression. J Biol Chem. 2010; 1285(1): 142–52.
• Harris C, et al., Dietary pyrroloquinoline quinone (PQQ) alters indicators of inflammation and mitochondrial-related metabolism in human subjects. Journal of Nutritional Biochemistry. 2013; 24: 2076–2084.
• He K, H. Nukada, T. Urakami, M.P. Murphy. Antioxidant and pro-oxidant properties of pyrroloquinoline quinone (PQQ): implications for its function in biological systems. Biochem Pharmacol. 2003; 65: 67–74.
• Koikeda T, M. Nereno, and K. Masuda. Pyrroloquinoline quinone disodium salt improves higher brain function. Medical Consultation & New Remedies. 2011; 48(5): 59-67.
• Kumazawa T, K. Sato, H. Seno, A. Ishii, O. Suzuki. Levels of pyrroloquinoline quinone in various foods. Biochem J. 1995; 15(307 Pt 2): 331–3.
• Nakano M, K. Ubukata, T. Yamamoto, H. Yamaguchi. Effect of pyrroloquinoline quinone (PQQ) on mental status of middle-aged and elderly persons. FOOD Style 21. 2009; 13(7): 50–3.
• Nakano M, et al. Effects of Oral Supplementation with Pyrroloquinoline Quinone on Stress, Fatigue, and Sleep. Functional Foods in Health and Disease. 2012; 2(8): 307–24.
• Rucker R, A. Ouchi, I. Nakano, S. Nagaoka, K. Mukai. Kinetic study of the antioxidant activity of pyrroloquinoline quinol (PQQH2, a reduced form of pyrroloquinoline quinone) in micellar solution. J Agric Food Chem. 2009; 57: 450–56.
• Stites TE, A.E. Mitchell, R.B. Rucker. Physiological importance of quinoenzymes and the O-quinone family of cofactors. J Nutr. 2000; 130(4): 719–27.

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